Glutathione Biosynthesis via Activation of the Nuclear Factor E2-Related Factor 2 (Nrf2) - Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate

• Main Authors: Keita Mizuno (Author), Toshiaki Kume (Author), Chie Muto (Author), Yuki Takada-Takatori (Author), Yasuhiko Izumi (Author), Hachiro Sugimoto (Author), Akinori Akaike (Author)
• Format: Book
• Published: Elsevier, 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress plays pivotal roles in aging, neurodegenerative disease, and pathological conditions such as ischemia. We investigated the effect of sulforaphane and 6-(methysulfinyl) hexyl isothiocyanate (6-HITC), a naturally occurring isothiocyanate, on oxidative stress-induced cytotoxicity using...