Repurposing econazole as a pharmacological autophagy inhibitor to treat pancreatic ductal adenocarcinoma

• Main Authors: Ningna Weng (Author), Siyuan Qin (Author), Jiayang Liu (Author), Xing Huang (Author), Jingwen Jiang (Author), Li Zhou (Author), Zhe Zhang (Author), Na Xie (Author), Kui Wang (Author), Ping Jin (Author), Maochao Luo (Author), Liyuan Peng (Author), Edouard C. Nice (Author), Ajay Goel (Author), Suxia Han (Author), Canhua Huang (Author), Qing Zhu (Author)
• Format: Book
• Published: Elsevier, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by the highest mortality among carcinomas. The pathogenesis of PDAC requires elevated autophagy, inhibition of which using hydroxychloroquine has shown promise. However, current realization is impeded by its suboptimal use and unpredictable to...