Intradiscal Injection of Induced Pluripotent Stem Cell-Derived Nucleus Pulposus-Like Cell-Seeded Polymeric Microspheres Promotes Rat Disc Regeneration

• Main Authors: Kaishun Xia (Author), Jian Zhu (Author), Jianming Hua (Author), Zhe Gong (Author), Chao Yu (Author), Xiaopeng Zhou (Author), Jingkai Wang (Author), Xianpeng Huang (Author), Wei Yu (Author), Liming Li (Author), Jianqing Gao (Author), Qixin Chen (Author), Fangcai Li (Author), Chengzhen Liang (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Cell replacement therapy is an attractive alternative for treating degenerated intervertebral discs (IVDs), which are related to the reduction of nucleus pulposus-like cells (NP-lCs) and the loss of the extracellular matrix. Induced pluripotent stem cells (iPSCs) which resemble embryonic...