The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole
PURPOSE. To evaluate the metabolism of amiodarone (AM) to desethylamiodarone (DEA) by selected human and rat cytochrome P450, and the inhibitory effect of ketoconazole (KTZ). METHODS. Some important CYP isoenzymes (rat CYP1A1, 1A2, 2C6, 2C11, 2D1, 2D2, and 3A1 and human CYP1A1, 1A2, 2D6 and 3A4) wer...
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| Main Authors: | , , |
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| Format: | Book |
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Frontiers Media S.A.,
2008-04-01T00:00:00Z.
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| Call Number: |
A1234.567 |
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| Copy 1 | Available |