Nicorandil Inhibits Osteoclast Formation Base on NF-κB and p-38 MAPK Signaling Pathways and Relieves Ovariectomy-Induced Bone Loss

• Main Authors: Shenggui Xu (Author), Xiankun Cao (Author), Zhenxing Yu (Author), Wenxin He (Author), Yichuan Pang (Author), Wang Lin (Author), Zhiqian Chen (Author), Weizhong Guo (Author), Xiongwei Lu (Author), Chengshou Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteolytic bone disorders are characterized by an overall reduction in bone mineral density which enhances bone ductility and vulnerability to fractures. This disorder is primarily associated with superabundant osteoclast formation and bone resorption activity. Nicorandil (NIC) is a vasodilatory ant...