Development and Stability of a New Formulation of Pentobarbital Suppositories for Paediatric Procedural Sedation

• Main Authors: Matthieu Lebrat (Author), Yassine Bouattour (Author), Coralie Gaudet (Author), Mouloud Yessaad (Author), Mireille Jouannet (Author), Mathieu Wasiak (Author), Imen Dhifallah (Author), Eric Beyssac (Author), Ghislain Garrait (Author), Philip Chennell (Author), Valérie Sautou (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pentobarbital is a drug of choice to limit motion in children during paediatric procedural sedations (PPSs). However, despite the rectal route being preferred for infants and children, no pentobarbital suppositories are marketed, and therefore they must be prepared by compounding pharmacies. In this...