Tolerogenic Lipid Nanoparticles for Delivering Self-Antigen mRNA for the Treatment of Experimental Autoimmune Encephalomyelitis

• Main Authors: Masaki Gomi (Author), Yuka Nakayama (Author), Yu Sakurai (Author), Ryotaro Oyama (Author), Koki Iwasaki (Author), Mizuki Doi (Author), Yi Liu (Author), Mizuho Hori (Author), Himeka Watanabe (Author), Kohei Hashimoto (Author), Hiroki Tanaka (Author), Kota Tange (Author), Yuta Nakai (Author), Hidetaka Akita (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Multiple sclerosis is a disease caused by autoantigen-responsive immune cells that disrupt the myelin in the central nervous system (CNS). Although immunosuppressive drugs are used to suppress symptoms, no definitive therapy exists. As in the experimental autoimmune encephalitis (EAE) model of multi...