Differential Expression of Matrix Metalloproteinases 2, 9 and Cytokines by Neutrophils and Monocytes in the Clinical Forms of Chagas Disease.

• Main Authors: Nayara I Medeiros (Author), Rafaelle C G Fares (Author), Eliza P Franco (Author), Giovane R Sousa (Author), Rafael T Mattos (Author), Ana T Chaves (Author), Maria do Carmo P Nunes (Author), Walderez O Dutra (Author), Rodrigo Correa-Oliveira (Author), Manoel O C Rocha (Author), Juliana A S Gomes (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dilated cardiomyopathy, the most severe manifestation in chronic phase of Chagas disease, affects about 30% of patients and is characterized by myocardial dysfunction and interstitial fibrosis due to extracellular matrix (ECM) remodeling. ECM remodeling is regulated by proteolytic enzymes such as ma...