Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer

• Main Authors: Ji Min Park (Author), Jei-Ming Peng (Author), Yu-Shiuan Shen (Author), Chia-Ying Lin (Author), Tung-Wei Hsu (Author), Yen-Hao Su (Author), Hsin-An Chen (Author), Charupong Saengboonmee (Author), Jung-Su Chang (Author), Ching-Feng Chiu (Author), Yan-Shen Shan (Author)
• Format: Book
• Published: Elsevier, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dicer is an enzyme that processes microRNAs (miRNAs) precursors into mature miRNAs, which have been implicated in various aspects of cancer progressions, such as clinical aggressiveness, prognosis, and survival outcomes. We previously showed that high expression of Dicer is associated wit...