Syndrome in question

• Main Authors: Isy Lima Peixoto (Author), Ana Maria Carreno (Author), Vania Mesquita Gadelha Prazeres (Author), Caroline Albuquerque Rodrigues Chirano (Author), Gabriel Maroja Ihara (Author), Patricia Bandeira de Melo Akel (Author)
• Format: Bog
• Udgivet: Sociedade Brasileira de Dermatologia, 2014-12-01T00:00:00Z.
• Fag: article
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Costello syndrome (CS) is a rare genetic disorder, first described by Costello in 1971, caused by mutations in the HRAS proto-oncogene. Clinical findings include facial dysmorphism, skin disorders, cognitive impairment, cardiac and musculoskeletal defects. There is an increased risk of malignancies...