In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
Cruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi infection a...
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フォーマット: | 図書 |
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Public Library of Science (PLoS),
2010-09-01T00:00:00Z.
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A1234.567 |
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所蔵 1 | 利用可 |