In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

• Main Authors: Yen Ting Chen (Author), Linda S Brinen (Author), Iain D Kerr (Author), Elizabeth Hansell (Author), Patricia S Doyle (Author), James H McKerrow (Author), William R Roush (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi infection a...