In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.

Cruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease. As a proof-of-concept, K11777, a potent inhibitor of cruzain, was found to effectively eliminate T. cruzi infection a...

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主要な著者: Yen Ting Chen (著者), Linda S Brinen (著者), Iain D Kerr (著者), Elizabeth Hansell (著者), Patricia S Doyle (著者), James H McKerrow (著者), William R Roush (著者)
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出版事項: Public Library of Science (PLoS), 2010-09-01T00:00:00Z.
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3rd Floor Main Library

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請求記号: A1234.567
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