Comparison of Compartmental and Non-Compartmental Analysis to Detect Biopharmaceutical Similarity of Intravenous Nanomaterial-Based Rifabutin Formulations

• Main Authors: Nadezhda Osipova (Author), Andrey Budko (Author), Olga Maksimenko (Author), Elena Shipulo (Author), Ludmila Vanchugova (Author), Wenqian Chen (Author), Svetlana Gelperina (Author), Matthias G. Wacker (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacometric analysis is often used to quantify the differences and similarities between formulation prototypes. In the regulatory framework, it plays a significant role in the evaluation of bioequivalence. While non-compartmental analysis provides an unbiased data evaluation, mechanistic compartm...