Hybrids of Imatinib with Quinoline: Synthesis, Antimyeloproliferative Activity Evaluation, and Molecular Docking

• المؤلفون الرئيسيون: Carine Santos (مؤلف), Luiz Pimentel (مؤلف), Henayle Canzian (مؤلف), Andressa Oliveira (مؤلف), Floriano Junior (مؤلف), Rafael Dantas (مؤلف), Lucas Hoelz (مؤلف), Debora Marinho (مؤلف), Anna Cunha (مؤلف), Monica Bastos (مؤلف), Nubia Boechat (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Imatinib (IMT) is the first-in-class BCR-ABL commercial tyrosine kinase inhibitor (TKI). However, the resistance and toxicity associated with the use of IMT highlight the importance of the search for new TKIs. In this context, heterocyclic systems, such as quinoline, which is present as a pharmacoph...