β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury

• Main Authors: Ziyue Zhang (Author), Xingbing Li (Author), Jingwen Guo (Author), Bo He (Author), Lianpan Wu (Author), Rongpei Yang (Author), Xingyue Li (Author), Dandong Fang (Author), XiaoLi Yang (Author), Donghai Yang (Author), Fengxian Wang (Author), Ming Tang (Author), Yu Han (Author), Pedro A. Jose (Author), Hongyong Wang (Author), Chunyu Zeng (Author)
• Format: Book
• Published: BMC, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive molecules generated by BCAA metabolites. L-β-aminoiso...