Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

• Main Authors: Yan Peng (Author), Ying Peng (Author), Wei Zhang (Author), Siyi Zhang (Author), Huiqian Peng (Author), Zhen Li (Author), Bo Li (Author), Linyi Liu (Author), Linsheng Zhuo (Author), Zhen Wang (Author), Junbo Wu (Author), Weifan Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionN-phenyl-2-(aniline) analog N53 is a previously discovered dual inhibitor of Topo I and COX-2, which exhibited significant anti-colon cancer activity in vitro, but the poor solubility and moderate anti-cancer activity in vivo hindered its further development.MethodsTo rectify the subopti...