The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis

• Autori principali: Jenni Lahtela (Autore), Barun Pradhan (Autore), Katja Närhi (Autore), Annabrita Hemmes (Autore), Merja Särkioja (Autore), Panu E. Kovanen (Autore), Arthur Brown (Autore), Emmy W. Verschuren (Autore)
• Natura: Libro
• Pubblicazione: The Company of Biologists, 2015-04-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Treatment of non-small cell lung cancer (NSCLC) is based on histological analysis and molecular profiling of targetable driver oncogenes. Therapeutic responses are further defined by the landscape of passenger mutations, or loss of tumor suppressor genes. We report here a thorough study to address t...