Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling

• Main Authors: Zhouhua Wang (Author), Zixin He (Author), Lei Zhang (Author), Haohao Zhang (Author), Meimei Zhang (Author), Xinguo Wen (Author), Guilan Quan (Author), Xintian Huang (Author), Xin Pan (Author), Chuanbin Wu (Author)
• Format: Book
• Published: Elsevier, 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To prepare a stable complex of doxycycline (Doxy) and hydroxypropy-β-cyclodextrin (HP-β-CD) for ophthalmic delivery, the optimum formulation and preparation conditions were investigated using response surface methodology (RSM), artificial neural network (ANN) and support vector machine (SVM) modelin...