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Optimization of a doxycycline hydroxypropyl-β-cyclodextrin inclusion complex based on computational modeling

To prepare a stable complex of doxycycline (Doxy) and hydroxypropy-β-cyclodextrin (HP-β-CD) for ophthalmic delivery, the optimum formulation and preparation conditions were investigated using response surface methodology (RSM), artificial neural network (ANN) and support vector machine (SVM) modelin...

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Main Authors: Zhouhua Wang (Author), Zixin He (Author), Lei Zhang (Author), Haohao Zhang (Author), Meimei Zhang (Author), Xinguo Wen (Author), Guilan Quan (Author), Xintian Huang (Author), Xin Pan (Author), Chuanbin Wu (Author)
Format: Book
Published: Elsevier, 2013-04-01T00:00:00Z.
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