First‐in‐human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor

First‐in‐human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor

Abstract Dysregulation of the mineralocorticoid hormone aldosterone is an increasingly prevalent cause of hypertension. Aldosterone synthase (CYP11B2) shares 93% homology to 11β‐hydroxylase (CYP11B1), which produces cortisol. Lorundrostat, a highly selective inhibitor of CYP11B2, is a potential safe...

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Main Authors: Hidetoshi Shimizu (Author), Michael A. Tortorici (Author), Yoshiyasu Ohta (Author), Kei Ogawa (Author), Sheikh Mohammed Ashfaq Rahman (Author), Aya Fujii (Author), Yuki Hiraga (Author), Mizue Kawai (Author), Kanami Sugimoto‐Kawabata (Author), Mattheus (Thijs) (Author), Jan Jaap vanLier (Author), Stephen Djedjos (Author), B. T. Slingsby (Author), David M. Rodman (Author)
Format: Book
Published: Wiley, 2024-08-01T00:00:00Z.
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