Synthesis, Fluorine-18 Radiolabeling, and In Vivo PET Imaging of a Hydrophilic Fluorosulfotetrazine

• المؤلفون الرئيسيون: Jason Beaufrez (مؤلف), Stéphane Guillouet (مؤلف), Yann Seimbille (مؤلف), Cécile Perrio (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

The development of ¹⁸F-fluorotetrazines, suitable for the radiolabeling of biologics such as proteins and antibodies by IEDDA ligation, represents a major challenge, especially for pre-targeting applications. The hydrophilicity of the tetrazine has clearly become a crucial par...