Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum.

• Main Authors: Sarah Hendrickx (Author), Magali Van den Kerkhof (Author), Dorien Mabille (Author), Paul Cos (Author), Peter Delputte (Author), Louis Maes (Author), Guy Caljon (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Since miltefosine monotherapy against visceral leishmaniasis (VL) caused by Leishmania donovani has been discontinued in the Indian subcontinent due to an increase in the number of treatment failures, single dose liposomal amphotericin B is now advocated as a treatment option of choice. P...