Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors

We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer's agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (CAS); a hydrocarbon tether with variable...

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Main Authors: Ana I. Ahuja-Casarín (Author), Penélope Merino-Montiel (Author), José Luis Vega-Baez (Author), Sara Montiel-Smith (Author), Miguel X. Fernandes (Author), Irene Lagunes (Author), Inés Maya (Author), José M. Padrón (Author), Óscar López (Author), José G. Fernández-Bolaños (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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