Tuning the activity of iminosugars: novel N-alkylated deoxynojirimycin derivatives as strong BuChE inhibitors
We have designed unprecedented cholinesterase inhibitors based on 1-deoxynojirimycin as potential anti-Alzheimer's agents. Compounds are comprised of three key structural motifs: the iminosugar, for interaction with cholinesterase catalytic anionic site (CAS); a hydrocarbon tether with variable...
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Main Authors: | Ana I. Ahuja-Casarín (Author), Penélope Merino-Montiel (Author), José Luis Vega-Baez (Author), Sara Montiel-Smith (Author), Miguel X. Fernandes (Author), Irene Lagunes (Author), Inés Maya (Author), José M. Padrón (Author), Óscar López (Author), José G. Fernández-Bolaños (Author) |
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Format: | Book |
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Taylor & Francis Group,
2021-01-01T00:00:00Z.
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Online Access: | Connect to this object online. |
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