Salt-inducible kinase inhibition promotes the adipocyte thermogenic program and adipose tissue browning

• Main Authors: Fubiao Shi (Author), Flaviane de Fatima Silva (Author), Dianxin Liu (Author), Hari U. Patel (Author), Jonathan Xu (Author), Wei Zhang (Author), Clara Türk (Author), Marcus Krüger (Author), Sheila Collins (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Norepinephrine stimulates the adipose tissue thermogenic program through a β-adrenergic receptor (βAR)-cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) signaling cascade. We discovered that a noncanonical activation of the mechanistic target of rapamycin complex 1 (mTORC1) by...