CAR-J cells for antibody discovery and lead optimization of TCR-like immunoglobulins

• Main Authors: Christian Jost (Author), Diana Darowski (Author), John Challier (Author), Vesna Pulko (Author), Lydia J Hanisch (Author), Wei Xu (Author), Ekkehard Mössner (Author), Alexander Bujotzek (Author), Stefan Klostermann (Author), Pablo Umana (Author), Roland E. Kontermann (Author), Christian Klein (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T-cell bispecific antibodies (TCBs) are a novel class of engineered immunoglobulins that unite monovalent binding to the T-cell receptor (TCR) CD3e chain and bivalent binding to tumor-associated antigens in order to recruit and activate T-cells for tumor cell killing. In vivo, T-cell activation is u...