Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice

• Main Authors: Linlin Zhang (Author), Niccolò Terrando (Author), Zhen-Zhong Xu (Author), Sangsu Bang (Author), Sven-Eric Jordt (Author), William Maixner (Author), Charles N. Serhan (Author), Ru-Rong Ji (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit inflammatory and neuropathic pain. In this study, we ex...