Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells

• Main Authors: Romeo Romagnoli (Author), Filippo Prencipe (Author), Luisa Carlota Lopez-Cara (Author), Paola Oliva (Author), Stefania Baraldi (Author), Pier Giovanni Baraldi (Author), Francisco Estévez-Sarmiento (Author), José Quintana (Author), Francisco Estévez (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The combination of two pharmacophores into a single molecule represents one of the methods that can be adopted for the synthesis of new anticancer molecules. To investigate the influence of the position of the pyridine nitrogen on biological activity, two different series of α-bromoacryloylamido ind...