Upregulation of IRF9 Contributes to Pulmonary Artery Smooth Muscle Cell Proliferation During Pulmonary Arterial Hypertension

• Main Authors: Yong-Jie Chen (Author), Yi Li (Author), Xian Guo (Author), Bo Huo (Author), Yue Chen (Author), Yi He (Author), Rui Xiao (Author), Xue-Hai Zhu (Author), Ding-Sheng Jiang (Author), Xiang Wei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abnormal proliferation of pulmonary artery smooth muscle cells (PASMCs) is a critical pathological feature in the pathogenesis of pulmonary arterial hypertension (PAH), but the regulatory mechanisms remain largely unknown. Herein, we demonstrated that interferon regulatory factor 9 (IRF9) accelerate...