The Influence of Milling on the Dissolution Performance of Simvastatin

• मुख्य लेखकों: Thomas Rades (लेखक), Clare J. Strachan (लेखक), Ulrike Zimper (लेखक), Jaakko Aaltonen (लेखक), Keith C. Gordon (लेखक), Karen Krauel-Goellner (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2010-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Particle size reduction is a simple means to enhance the dissolution rate of poorly water soluble BCS-class II and IV drugs. However, the major drawback of this process is the possible introduction of process induced disorder. Drugs with different molecular arrangements may exhibit altered propertie...