A novel small molecule, CU05-1189, targeting the pleckstrin homology domain of PDK1 suppresses VEGF-mediated angiogenesis and tumor growth by blocking the Akt signaling pathway

• Main Authors: Jeongeun Park (Author), Haiying Zhang (Author), Hyun Jung Kwak (Author), Changdev Gorakshnath Gadhe (Author), Yeomyeong Kim (Author), Hyejeong Kim (Author), Minyoung Noh (Author), Dongyun Shin (Author), Sang-Jun Ha (Author), Young-Guen Kwon (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inhibition of angiogenesis is considered a promising therapeutic approach for cancer treatment. Our previous genetic research showed that the use of a cell-penetrating peptide to inhibit the pleckstrin homology (PH) domain of 3-phosphoinositide-dependent kinase 1 (PDK1) was a viable approach to supp...