Pharmacological blockade of protease-Activated Receptor 2 improves airway remodeling and lung inflammation in experimental allergic asthma

• Main Authors: Natália Alves de Matos (Author), Diego Carlos dos Reis (Author), Lucas Kraemer Rocha (Author), Matheus Silvério de Mattos (Author), Geovanni Dantas Cassali (Author), Remo Castro Russo (Author), Andrea de Castro Perez (Author), André Klein (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Protease-activated receptors (PARs) are metabotropic G-protein-coupled receptors that are activated via proteolytic cleavage of a specific sequence of amino acids in their N-terminal region. PAR2 has been implicated in mediating allergic airway inflammation. This study aims to study the eff...