Characterization Of Selective TRPM8 Ligands And Their Structure Activity Response (S.A.R) Relationship

• Main Authors: Muhammad Azhar Sherkheli (Author), Angela K. Vogt-Eisele (Author), Daniel Bura (Author), Leopoldo R. Beltrán Márques (Author), Günter Gisselmann (Author), Hanns Hatt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2010-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE: Transient receptor potential melastatin-8 (TRPM8) is an ion channel expressed extensively in sensory nerves, human prostate and overexpressed in a variety of cancers including prostate, breast, lung, colon and skin melanomas. It is activated by innoxious cooling and chemical stimuli. TRPM8...