P-Selectin Targeted Dexamethasone-Loaded Lipid Nanoemulsions: A Novel Therapy to Reduce Vascular Inflammation

• Main Authors: Viorel Simion (Author), Cristina Ana Constantinescu (Author), Daniela Stan (Author), Mariana Deleanu (Author), Monica Madalina Tucureanu (Author), Elena Butoi (Author), Ileana Manduteanu (Author), Maya Simionescu (Author), Manuela Calin (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammation is a common process associated with numerous vascular pathologies. We hypothesized that targeting the inflamed endothelium by coupling a peptide with high affinity for P-selectin to the surface of dexamethasone-loaded lipid nanoemulsions will highly increase their specific binding to ac...