Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2

• Main Authors: Zhen-Hua Zhu (Author), Xu-Yuan Yin (Author), Tu-Sun Xu (Author), Wei-Wei Tao (Author), Guang-Da Yao (Author), Pei-Jie Wang (Author), Qi Qi (Author), Qiu-Fang Jia (Author), Jing Wang (Author), Yue Zhu (Author), Li Hui (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Morinda officinalis oligosaccharides (MOs) are natural herbal extracts that have been shown to exert antidepressant effects. However, the mechanism of this effect remains unclear. Here, we explored the mechanism by which MOs improved experimental depression. Using a chronic mild stress (CMS) murine...