Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy

• Main Authors: Lei Ren (Author), Hao-Nan Guo (Author), Jun Yang (Author), Xiao-Ying Guo (Author), Ye-Sheng Wei (Author), Zhao Yang (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Taxifolin (TFN) is an important natural compound with antifibrotic activity; however, its pharmacological mechanism is not clear. In this study, our aim is to gain insight into the effects of TFN and its potential mechanisms in unilateral ureteral obstruction (UUO) animal model using metabolomics ap...