Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells

• Main Authors: M. A. Taipov (Author), Z. N. Nikiforova (Author), O. M. Pavlova (Author), I. A. Kudryavtsev (Author), N. Ye. Arnotskaya (Author), V. Ye. Shevchenko (Author)
• Format: Book
• Published: ABV-press, 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen rec...