Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells

• Egile Nagusiak: M. A. Taipov (Egilea), Z. N. Nikiforova (Egilea), O. M. Pavlova (Egilea), I. A. Kudryavtsev (Egilea), N. Ye. Arnotskaya (Egilea), V. Ye. Shevchenko (Egilea)
• Formatua: Liburua
• Argitaratua: ABV-press, 2014-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen rec...