Role of TGF-β1/SMAD signaling cascade in the regulation of cyclooxygenase-2 expression in human breast cancer cells

• Κύριοι συγγραφείς: M. A. Taipov (Συγγραφέας), Z. N. Nikiforova (Συγγραφέας), O. M. Pavlova (Συγγραφέας), I. A. Kudryavtsev (Συγγραφέας), N. Ye. Arnotskaya (Συγγραφέας), V. Ye. Shevchenko (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: ABV-press, 2014-07-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Περίληψη

The expression of the SMAD2, SMAD4, SMAD7, and СOX-2 genes and the levels of Smad4, phosphorylated Smad2, and Smad7 proteins were analyzed in the human breast cancer (BC) cell lines MCF-7, BT-474, and ZR-75-1. The SMAD2 and SMAD4 genes were found to suppress COX-2 gene expression in the estrogen receptor-positive BC cells and to be linked to their metastatic potential. Smad4 and Smad2 apparently suppress COX-2 mRNA and protein synthesis and Smad7 is their antagonist and stimulates COX-2 formation. Smad2, Smad4, Smad7 proteins may be regarded as new potential targets for targeted BC therapy.

Περιγραφή τεκμηρίου

1994-4098
1999-8627
10.17650/1994-4098-2013-0-1-2-6-12