Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance

• Main Authors: Alan C. Rupp (Author), Margaret B. Allison (Author), Justin C. Jones (Author), Christa M. Patterson (Author), Chelsea L. Faber (Author), Nadejda Bozadjieva (Author), Lora K. Heisler (Author), Randy J. Seeley (Author), David P. Olson (Author), Martin G. Myers, Jr (Author)
• Format: Book
• Published: Elsevier, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: To date, early developmental ablation of leptin receptor (LepRb) expression from circumscribed populations of hypothalamic neurons (e.g., arcuate nucleus (ARC) Pomc- or Agrp-expressing cells) has only minimally affected energy balance. In contrast, removal of LepRb from at least two large...