MRI-derived radiomics assessing tumor-infiltrating macrophages enable prediction of immune-phenotype, immunotherapy response and survival in glioma

• Main Authors: Di Chen (Author), Rui Zhang (Author), Xiaoming Huang (Author), Chunxia Ji (Author), Wei Xia (Author), Ying Qi (Author), Xinyu Yang (Author), Lishuang Lin (Author), Jing Wang (Author), Haixia Cheng (Author), Weijun Tang (Author), Jinhua Yu (Author), Dave S. B. Hoon (Author), Jun Zhang (Author), Xin Gao (Author), Yu Yao (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The tumor immune microenvironment can influence the prognosis and treatment response to immunotherapy. We aimed to develop a non-invasive radiomic signature in high-grade glioma (HGG) to predict the absolute density of tumor-associated macrophages (TAMs), the preponderant immune...