A human beta cell line with drug inducible excision of immortalizing transgenes

• Main Authors: Marion Benazra (Author), Marie-José Lecomte (Author), Claire Colace (Author), Andreas Müller (Author), Cécile Machado (Author), Severine Pechberty (Author), Emilie Bricout-Neveu (Author), Maud Grenier-Godard (Author), Michele Solimena (Author), Raphaël Scharfmann (Author), Paul Czernichow (Author), Philippe Ravassard (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Access to immortalized human pancreatic beta cell lines that are phenotypically close to genuine adult beta cells, represent a major tool to better understand human beta cell physiology and develop new therapeutics for Diabetes. Here we derived a new conditionally immortalized human beta...