Chemically Synthesized Alcaligenes Lipid A as an Adjuvant to Augment Immune Responses to Haemophilus Influenzae Type B Conjugate Vaccine

• Main Authors: Zilai Liu (Author), Koji Hosomi (Author), Atsushi Shimoyama (Author), Ken Yoshii (Author), Xiao Sun (Author), Huangwenxian Lan (Author), Yunru Wang (Author), Haruki Yamaura (Author), Davie Kenneth (Author), Azusa Saika (Author), Takahiro Nagatake (Author), Hiroshi Kiyono (Author), Koichi Fukase (Author), Jun Kunisawa (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously identified Alcaligenes spp. as a commensal bacterium that resides in lymphoid tissues, including Peyer's patches. We found that Alcaligenes-derived lipopolysaccharide acted as a weak agonist of Toll-like receptor four due to the unique structure of lipid A, which lies in the core...