Coactivation of Tie2 and Wnt signaling using an antibody-R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

• Main Authors: Byungtae Hwang (Author), Min-Young Jeon (Author), Ju-Hong Jang (Author), Young-Lai Cho (Author), Dong Gwang Lee (Author), Jeong-Ki Min (Author), Jangwook Lee (Author), Jong-Gil Park (Author), Ji-Hun Noh (Author), Wonjun Yang (Author), Nam-Kyung Lee (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic angiogenesis by intentional formation of blood vessels is essential for treating various ischemic diseases, including limb ischemia. Because Wnt/β-catenin and angiopoietin-1/Tie2 signaling play important roles in endothelial survival and vascular stability, coactivation of these signalin...