Coactivation of Tie2 and Wnt signaling using an antibody-R-spondin fusion potentiates therapeutic angiogenesis and vessel stabilization in hindlimb ischemia

• Główni autorzy: Byungtae Hwang (Autor), Min-Young Jeon (Autor), Ju-Hong Jang (Autor), Young-Lai Cho (Autor), Dong Gwang Lee (Autor), Jeong-Ki Min (Autor), Jangwook Lee (Autor), Jong-Gil Park (Autor), Ji-Hun Noh (Autor), Wonjun Yang (Autor), Nam-Kyung Lee (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Therapeutic angiogenesis by intentional formation of blood vessels is essential for treating various ischemic diseases, including limb ischemia. Because Wnt/β-catenin and angiopoietin-1/Tie2 signaling play important roles in endothelial survival and vascular stability, coactivation of these signalin...