miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages

• Main Authors: Zhenyu Lu (Author), Jing Wang (Author), Xu Wang (Author), Zhiying Li (Author), Dan Niu (Author), Min Wang (Author), Jinzhu Xiang (Author), Yongli Yue (Author), Yajuan Xia (Author), Xueling Li (Author)
• Format: Book
• Published: Hindawi Limited, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human embryonic stem cells (hESCs) possess the ability to differentiate into insulin-producing cells (IPCs), which can be used to treat type I diabetes. miR-375 is an essential transcriptional regulator in the development and maturation of the pancreas. In this study, we optimized a protocol to diff...