A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

A library approach for the de novo high-throughput isolation of humanized VHH domains with favorable developability properties following camelid immunization

ABSTRACTIn this study, we generated a novel library approach for high throughput de novo identification of humanized single-domain antibodies following camelid immunization. To achieve this, VHH-derived complementarity-determining regions-3 (CDR3s) obtained from an immunized llama (Lama glama) were...

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Main Authors: Paul Arras (Author), Han Byul Yoo (Author), Lukas Pekar (Author), Christian Schröter (Author), Thomas Clarke (Author), Simon Krah (Author), Daniel Klewinghaus (Author), Vanessa Siegmund (Author), Andreas Evers (Author), Stefan Zielonka (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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3rd Floor Main Library

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