Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression

• Main Authors: Wen-Feng Fang (Author), Yu-Mu Chen (Author), Chiung-Yu Lin (Author), Hui-Lin Huang (Author), Hua Yeh (Author), Ya-Ting Chang (Author), Kuo-Tung Huang (Author), Meng-Chih Lin (Author)
• Format: Book
• Published: BMC, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Sepsis is a life-threatening organ dysfunction caused by dysregulated host response to infection, and is primarily characterized by an uncontrolled systemic inflammatory response. In the present study, we developed an effective adjunct therapy mediated by a novel mechanism, to at...