An Overview of the Relevance of IgG4 Antibodies in Allergic Disease with a Focus on Food Allergens

• Main Authors: Thomas A. E. Platts-Mills (Author), Behnam Keshavarz (Author), Jeffrey M. Wilson (Author), Rung-chi Li (Author), Peter W. Heymann (Author), Diane R. Gold (Author), Emily C. McGowan (Author), Elizabeth A. Erwin (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibodies of the IgG4 isotype are strongly associated with allergic disease but have several properties such as not precipitating with allergens, not activating complement and poor binding to Fcγ receptors that argue against a pro-inflammatory role. In keeping with that, IgG4 antibodies are a strik...