Discovering functional modules by identifying recurrent and mutually exclusive mutational patterns in tumors

• Main Authors: Aldape Kenneth D (Author), Sulman Erik P (Author), Settle Stephen H (Author), Miller Christopher A (Author), Milosavljevic Aleksandar (Author)
• Format: Book
• Published: BMC, 2011-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Assays of multiple tumor samples frequently reveal recurrent genomic aberrations, including point mutations and copy-number alterations, that affect individual genes. Analyses that extend beyond single genes are often restricted to e...