Functional high-throughput screen identifies microRNAs that promote butyrate-induced death in colorectal cancer cells

• Main Authors: Saira R. Ali (Author), Karen J. Humphreys (Author), Kaylene.J. Simpson (Author), Ross A. McKinnon (Author), Robyn Meech (Author), Michael Z. Michael (Author)
• 格式: 图书
• 出版: Elsevier, 2022-12-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

The gut fermentation product butyrate displays anti-cancer properties in the human proximal colon, including the ability to inhibit proliferation and induce apoptosis in colorectal cancer (CRC) cells. A natural histone deacetylase inhibitor (HDACi), butyrate can alter histone acetylation patterns in...