HPLC-MS/MS method for determination of betamethasone in human plasma with application to a dichorionic twin pregnancy pharmacokinetic and placental transfers studies

• Main Authors: Grazielle de Fátima Pinto Rodrigues (Author), Jhohann Richard de Lima Benzi (Author), Maria Paula Marques (Author), Elaine Christine Dantas Moisés (Author), Vera Lucia Lanchote (Author), Alessandra Cristina Marcolin (Author)
• Formato: Livro
• Publicado em: Universidade de São Paulo, 2023-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Betamethasone (BET) is a synthetic glucocorticoid recommended for pregnant women at imminent risk of preterm birth before 34 weeks to reduce neonatal complications. There are different techniques to describe BET plasma quantification. However, none quantified the plasmatic concentration of...