Curcumin Inhibits the Proteinase-Activated Receptor-2-Triggered Prostaglandin E2 Production by Suppressing Cyclooxygenase-2 Upregulation and Akt-Dependent Activation of Nuclear Factor-κB in Human Lung Epithelial Cells

• Main Authors: Kazumi Moriyuki (Author), Fumiko Sekiguchi (Author), Kaori Matsubara (Author), Hiroyuki Nishikawa (Author), Atsufumi Kawabata (Author)
• Formato: Livro
• Publicado em: Elsevier, 2010-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We performed this study to determine if curcumin affects pro-inflammatory responses to activation of proteinase-activated receptor-2 (PAR2) in human pulmonary adenocarcinoma A549 cells. Curcumin completely inhibited the PAR2-triggered prostaglandin E2 (PGE2) production, but notably not interleukin-8...